N-(Phenylacetyl)-L-alanine → HCID 22895054, compound

HRID 2180856Notes

Reaction equation

HRID 2180856 reaction equation
[C:1]1([CH2:7][C:8]([NH:10][C@H:11]([C:13]([OH:15])=O)[CH3:12])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH3:17][O:18][C:19](=[O:34])[C@H:20]([CH2:29][CH2:30][CH2:31][CH2:32][NH2:33])[NH:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23]>>[CH3:17][O:18][C:19](=[O:34])[C@H:20]([CH2:29][CH2:30][CH2:31][CH2:32][NH2:33])[N:21]([C:13](=[O:15])[C@H:11]([CH3:12])[NH:10][C:8](=[O:9])[CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[C:22]([O:24][C:25]([CH3:28])([CH3:26])[CH3:27])=[O:23]

Participants

3

Reactant 2

HCID 7004640N-(Phenylacetyl)-L-alanineHCID 18728485Boc-Lys-OMe.HCl

Product 1

HCID 22895054HCID 22895054, compound

Procedure

Following General Procedure A and using N-(phenylacetyl)-L-alanine (from Example B1 above) and N,-(tert-butoxycarbonyl)-L-lysine methyl ester hydrochloride (Bachem), the title compound was prepared as a solid (mp=119-121° C.). The reaction was monitored by tlc (Rf=0.46 in 90:10:1 CH2Cl2MeOHNH4OH).

Sources & evidence

ORD record
ord-d0a4f973fa7644cd8b3d95694f8749e8
Source dataset
uspto-grants-2005_05
Patent number
US06888022B2

Reaction notes

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