7-chloro-3-(piperidin-4-yl)-1H-indole → 7-Chloro-3-{1-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)butan-1-yl]piperidin-4-yl}-1H-indole, hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	7-chloro-3-(piperidin-4-yl)-1H-indole	HCID 12072036	—
Reactant	1-(4-Bromobutan-1-yl)-3,4-dihydroquinolin-2(1H)-one	HCID 12992368	—
Product	7-Chloro-3-{1-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)butan-1-yl]piperidin-4-yl}-1H-indole, hydrochloride	HCID 131724871	—

Reaction Steps

from 7-chloro-3-(piperidin-4-yl)-1H-indole and 1-(4-bromobutan-1-yl)-3,4-dihydroquinolin-2(1H)-one. Mp 253-254° C. 1H NMR (DMSO-d6): 1.55-1.65 (m, 2H); 1.75-1.85 (m, 2H); 2.05-2.25 (m, 4H); 2.55 (t, 2H); 2.90 (t, 2H); 2.95-3.15 (m, 5H); 3.55 (d, 2H); 3.95 (t, 2H); 6.95-7.05 (m, 2H); 7.15-7.30 (m, 5H); 7.70 (d, 1H); 10.60 (broad s, 1H); 11.30 (s, 1H). MS m/z: 436 (MH+), 289.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06890916B2
Source dataset	uspto-grants-2005_05
ORD ID	ord-51fcabde6c1047cb8616f4b15cf4572b
Source note	uspto-grants-2005_05