HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 22485437, compound → HCID 22485444, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 22485437 | HCID 22485437 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | HCID 22485444 | HCID 22485444 | 8.5% |
Reaction Steps
To crude (4-fluoro-benzyl)-methyl-(2-nitro-cyclohexyl)-amine (1.0 mMol) in (5:1) MeOH/H2O (30 mL) was added Raney-Nickel. The reaction mixture was placed under H2 (1 atm) and stirred for 16 h. The slurry was filtered through Celite and the volatiles removed in vacuo to yield N-(4-Fluoro-benzyl)-N-methyl-cyclohexane-1,2-diamine (20 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06890938B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-407f9418d5b04e989f56b3279fb54614 |
| Source note | uspto-grants-2005_05 |