Acetic Anhydride → HCID 22484967, compound

HRID 2181012Notes

Reaction equation

HRID 2181012 reaction equation
[C:1]([NH:5][S:6]([CH2:9][CH2:10][CH2:11][CH2:12][OH:13])(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:14](OC(=O)C)(=[O:16])[CH3:15]>N1C=CC=CC=1>[C:1]([NH:5][S:6]([CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14](=[O:16])[CH3:15])(=[O:7])=[O:8])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 22484955HCID 22484955, compound

Product 1

HCID 22484967HCID 22484967, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A crude product (1.17 g) of N-tert-butyl-4-hydroxybutane-sulfonamide was dissolved in pyridine (3.0 ml) and acetic anhydride (1.5 ml) was added, and the mixture was left standing at room temperature for 1 hr. The reaction mixture was concentrated to dryness under reduced pressure and the residue was partitioned between ethyl acetate and 1N hydrochloric acid. The organic layer was washed once with water and once with saturated brine, dried over magnesium sulfate and concentrated to dryness under reduced pressure to give N-tert-butyl-4-acetoxybutanesulfonamide (425 mg) as a pale-yellow oil.

Workup

  1. waitthe mixture was left
  2. concentrationThe reaction mixture was concentrated to dryness under reduced pressure
  3. customthe residue was partitioned between ethyl acetate and 1N hydrochloric acid
  4. washThe organic layer was washed once with water and once with saturated brine
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-36512cf2f46d426e8d26832aeb5028d7
Source dataset
uspto-grants-2005_05
Patent number
US06890934B2

Reaction notes

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