HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Hydantoinpropionic acid → 3-(2,5-Dioxo-4-imidazolidinyl)-n-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Hydantoinpropionic acid | HCID 782 | — |
| Reactant | Hydantoin | HCID 10006 | — |
| Reactant | 4-[(2-Methyl-4-quinolinyl)methoxy]benzenamine dihydrochloride | HCID 67305537 | — |
| Product | 3-(2,5-Dioxo-4-imidazolidinyl)-n-{4-[(2-methyl-4-quinolinyl)methoxy]phenyl}propanamide | HCID 10136786 | 47.8% |
Reaction Steps
(+/−)-5-hydantoinpropionic acid (Dakin; Am. Chem. J. 1910, 44, 49) (50 mg, 0.29 mmol) was coupled with 4-[(2-methyl-4-quinolinyl)methoxy]-aniline bis-HCl salt (213 mg, 0.63 mmol) using general coupling method A to give 58 mg (44%) of the product hydantoin. MS found: (M+H)+=419.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06890915B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-b133d73d633e42c8891fffba4597d8ac |
| Source note | uspto-grants-2005_05 |