Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 4-Bromo-2-methylquinoline | HCID 15560677 | — |
| Reactant | HCID 68893156 | HCID 68893156 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22392809 | HCID 22392809 | — |
Reaction Steps
To 1-methylcarboxyphenylboronic acid (1.0 g, 5.6 mmol) and 4-bromo-2-methylquinoline (1.24 g, 5.6 mmol) in THF/aq K2CO3 was added Pd(PPh3)4 and the reaction was heated to 70° C. for 16 hr. Aqueous workup using NaHCO3 and EtOAc, column chromatography and saponification using the same conditions as for Example 214 gave the final product. MS found: (M+H) 264.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06890915B2 |
|---|
| Source dataset | uspto-grants-2005_05 |
|---|
| ORD ID | ord-fed4482e91de41ecbb010de4f744c26c |
|---|
| Source note | uspto-grants-2005_05 |
|---|
