HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2181080Generated: November 3, 2026
Hydrochloric Acid → 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, hydrochloride (1:1)
https://huagongshe.com/reaction/2181080
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Amlodipine | HCID 2162 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, hydrochloride (1:1) | HCID 22228524 | — |
Reaction Steps
To 100 ml of methanol was added 12 ml of conc-hydrochloric acid. 54 g of amlodipine prepared in Reference Example 1 in 500 ml of methanol was added dropwise, followed by stirring at 23° C. for 3 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06890944B2 |
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| Source dataset | uspto-grants-2005_05 |
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| ORD ID | ord-de6e8cde4009489eb734545c4d36d797 |
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| Source note | uspto-grants-2005_05 |
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