Cyclohexanesulfonamide → HCID 72613053, compound

HRID 2181096Notes

Reaction equation

HRID 2181096 reaction equation
CC1(C)[O:6][C:5](=[CH:7][C:8]([N:10]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[O:11][CH3:12])=[O:9])[C:4](=[O:21])O1.[CH:23]1([S:29]([NH2:32])(=[O:31])=[O:30])[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1>>[F:20][C:17]1[CH:16]=[CH:15][C:14]([CH2:13][N:10]([O:11][CH3:12])[C:8](=[O:9])[CH:7]=[C:5]([OH:6])[C:4]([NH:32][S:29]([CH:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)(=[O:31])=[O:30])=[O:21])=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 75536CyclohexanesulfonamideHCID 730332332-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide

Product 1

HCID 72613053HCID 72613053, compound

Procedure

2-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide was treated with cyclohexanesulfonic acid amide as described in the preparation of compound 1 to yield the title compound. LCMS (M+H) calcd for C18H24FN2O6S: 415.1; found: 415.0. 1H NMR (500 MHz, CDCl3) δ: 1.19 (overlapping m, 30,1.63 (overlapping m, 3), 1.90 (br m, 2), 2.17 (m, 2), 3.51 (m, 1), 3.69 (s, 3), 4.78 (s, 2), 6.53 (s, 1), 7.00 (m, 2), 7.26 (m, 2).

Sources & evidence

ORD record
ord-a689580bfeef461790ebe74bfa17ae05
Source dataset
uspto-grants-2005_05
Patent number
US06890942B2

Reaction notes

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