Cyclopropanesulfonamide → HCID 72613061, compound

HRID 2181098Notes

Reaction equation

HRID 2181098 reaction equation
CC1(C)[O:6][C:5](=[CH:7][C:8]([N:10]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[O:11][CH3:12])=[O:9])[C:4](=[O:21])O1.[CH:23]1([S:26]([NH2:29])(=[O:28])=[O:27])[CH2:25][CH2:24]1>>[F:20][C:17]1[CH:16]=[CH:15][C:14]([CH2:13][N:10]([O:11][CH3:12])[C:8](=[O:9])[CH:7]=[C:5]([OH:6])[C:4]([NH:29][S:26]([CH:23]2[CH2:25][CH2:24]2)(=[O:28])=[O:27])=[O:21])=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 15765418CyclopropanesulfonamideHCID 730332332-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide

Product 1

HCID 72613061HCID 72613061, compound

Procedure

2-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide was treated with cyclopropanesulfonic acid amide as described in the preparation of compound 1 to yield the title compound. LCMS (M+H) calcd for C15H18FN2O6S: 373.1; found: 373.0. 1H NMR (500 MHz, CDCl3) δ: 1.13 (m, 2), 1.44 (m, 2), 2.95 (m, 1), 3.68 (s, 3), 4.79 (s, 2), 6.55 (s, 1), 7.02 (m, 2), 7.29 (m, 2), 8.95 (s, 1). 13C NMR (125 MHz, CDCl3) δ: 6.45, 31.41, 48.31, 63.22, 92.45, 115.71, 115.88, 130.25, 130.32, 131.09, 159.44, 159.74, 161.70, 163.67, 170.98.

Sources & evidence

ORD record
ord-e412bb09b1d94852931994bfa6e7851e
Source dataset
uspto-grants-2005_05
Patent number
US06890942B2

Reaction notes

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