3,5-Dimethylisoxazole-4-sulfonamide → HCID 72613060, compound

Participants

Role	Name	HCID	Charge
Reactant	3,5-Dimethylisoxazole-4-sulfonamide	HCID 4962303	—
Reactant	2-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide	HCID 73033233	—
Product	HCID 72613060	HCID 72613060	—

Reaction Steps

2-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide was treated with 3,5-dimethyl-isoxazole-4-sulfonic acid amide as described in the preparation of compound 1 to yield the title compound. LCMS (M+H) calcd for C17H19FN3O7S: 428.1; found: 428.0. 1H NMR (500 MHz, CDCl3) δ: 2.44 (s, 3), 2.75 (s, 3), 3.65 (s, 3), 4.77 (s, 2), 6.45 (s, 1), 7.01 (m, 2), 7.26 (m, 2). 13C NMR (125 MHz, CDCl3) δ:10.83, 13.24, 48.33, 63.23, 92.57, 114.23, 115.71, 115.89, 130.19, 130.29, 130.96, 157.85, 158.89, 159.44, 161.71, 163.68, 170.81, 177.09.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06890942B2
Source dataset	uspto-grants-2005_05
ORD ID	ord-d729bd5b582b42238cec8b5c57ce42e2
Source note	uspto-grants-2005_05