Hydrazine → 8-(N-methylpiperazinyl)octylamine

HRID 21811Notes

Reaction equation

HRID 21811 reaction equation
[NH2:1]N.[CH3:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH:5]1[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]C1C=CC=C2C(NC(=O)C=12)=O>CO>[CH3:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH:5]1[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH2:1]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 538031688-(N-methylpiperazinyl)octylphthalimide

Product 1

HCID 539190598-(N-methylpiperazinyl)octylamine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Hydrazine (aqueous solution at 35% by wt.) (0.15 ml; 1.6 mmoles) was added to 8-(N-methylpiperazinyl)octylphthalimide (285 mg; 0.8 mmoles) in methanol (5 ml) and the resulting solution was refluxed. Reaction times and process as per Example 1.

Workup

  1. temperaturethe resulting solution was refluxed
  2. customReaction times and process as per Example 1

Sources & evidence

ORD record
ord-cfce7bd379f84345a73dc6362bf3c751
Source dataset
uspto-grants-1995_06
Patent number
US05424451

Reaction notes

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