1-methyl-1H-imidazole-4-sulfonamide → HCID 72613071, compound

HRID 2181105Notes

Reaction equation

HRID 2181105 reaction equation
CC1(C)[O:6][C:5](=[CH:7][C:8]([N:10]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[O:11][CH3:12])=[O:9])[C:4](=[O:21])O1.[CH3:23][N:24]1[CH:28]=[C:27]([S:29]([NH2:32])(=[O:31])=[O:30])[N:26]=[CH:25]1>>[F:20][C:17]1[CH:16]=[CH:15][C:14]([CH2:13][N:10]([O:11][CH3:12])[C:8](=[O:9])[CH:7]=[C:5]([OH:6])[C:4]([NH:32][S:29]([C:27]2[N:26]=[CH:25][N:24]([CH3:23])[CH:28]=2)(=[O:31])=[O:30])=[O:21])=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 27368851-methyl-1H-imidazole-4-sulfonamideHCID 730332332-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide

Product 1

HCID 72613071HCID 72613071, compound

Procedure

2-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide was treated with 1-methyl-1H-imidazole-4-sulfonic acid amide as described in the preparation of compound 1 to yield the title compound. 1H NMR (500 MHz, CDCl3) δ: 3.63 (s, 3), 3.83 (s, 3), 4.75 (s, 2), 6.40 (s, 1), 7.02 (m, 2), 7.27 (m, 2), 7.74 (s, 1), 7.80 (s, 1). 13C NMR (125 MHz, CDCl3) δ: 34.75, 48.21, 63.10, 92.33, 115.65, 115.82, 127.65, 130.24, 130.34, 131.11, 136.85, 139.42, 159.30, 159.55, 161.67, 163.63, 170.81.

Sources & evidence

ORD record
ord-50861fec790d4daaaa243bcfac42f091
Source dataset
uspto-grants-2005_05
Patent number
US06890942B2

Reaction notes

Loading…