HCID 2820331, compound → HCID 72613062, compound

HRID 2181107Notes

Reaction equation

HRID 2181107 reaction equation
CC1(C)[O:6][C:5](=[CH:7][C:8]([N:10]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[O:11][CH3:12])=[O:9])[C:4](=[O:21])O1.[CH3:23][N:24]1[C:28]([C:29]([F:32])([F:31])[F:30])=[CH:27][C:26]([C:33]2[S:37][C:36]([S:38]([NH2:41])(=[O:40])=[O:39])=[CH:35][CH:34]=2)=[N:25]1>>[F:20][C:17]1[CH:16]=[CH:15][C:14]([CH2:13][N:10]([O:11][CH3:12])[C:8](=[O:9])[CH:7]=[C:5]([OH:6])[C:4]([NH:41][S:38]([C:36]2[S:37][C:33]([C:26]3[CH:27]=[C:28]([C:29]([F:31])([F:30])[F:32])[N:24]([CH3:23])[N:25]=3)=[CH:34][CH:35]=2)(=[O:40])=[O:39])=[O:21])=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 2820331HCID 2820331, compoundHCID 730332332-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide

Product 1

HCID 72613062HCID 72613062, compound

Procedure

2-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide was treated with 5-(1-methyl-5-trifluoromethyl-1H-pyrazol-3-yl)-thiophene-2-sulfonic acid amide as described in the preparation of compound 1 to yield the title compound. 1H NMR (500 MHz, CDCl3) δ: 3.66 (s, 3), 4.03 (s, 3), 4.76 (s, 2), 6.50 (s, 1), 6.71 (s, 1), 7.00 (m, 2), 7.20 (m, 1), 7.25 (m, 2), 7.93 (m, 1).

Sources & evidence

ORD record
ord-beddd2cb0dad486fa6bad7c340bf96cf
Source dataset
uspto-grants-2005_05
Patent number
US06890942B2

Reaction notes

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