HCID 22499360, compound → HCID 72613068, compound

HRID 2181108Notes

Reaction equation

HRID 2181108 reaction equation
CC1(C)[O:6][C:5](=[CH:7][C:8]([N:10]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[O:11][CH3:12])=[O:9])[C:4](=[O:21])O1.[CH2:23]([C:26]1([S:29]([NH2:32])(=[O:31])=[O:30])[CH2:28][CH2:27]1)[CH2:24][CH3:25]>>[F:20][C:17]1[CH:16]=[CH:15][C:14]([CH2:13][N:10]([O:11][CH3:12])[C:8](=[O:9])[CH:7]=[C:5]([OH:6])[C:4](=[O:21])[NH:32][S:29]([C:26]2([CH2:23][CH2:24][CH3:25])[CH2:28][CH2:27]2)(=[O:31])=[O:30])=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 22499360HCID 22499360, compoundHCID 730332332-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide

Product 1

HCID 72613068HCID 72613068, compound

Procedure

2-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide was treated with 1-propyl-cyclopropanesulfonic acid amide as described in the preparation of compound 1 to yield the title compound. MS (M−H) calcd for C18H22FN2O6S: 413.1. Found: 413.0. 1H NMR (500 MHz, CDCl3) δ: 0.92 (t, 3, J=8), 1.00 (m, 2), 1.54 (m, 2), 1.74 (m, 2), 1.84 (m, 2), 3.68 (s, 3), 4.79 (s, 2), 6.54 (s, 1), 7.04 (m, 2), 7.29 (m, 2), 8.79 (s, 1). Anal calcd for C18H23FN2O6S: C, 52.16; H, 5.59; N, 6.76. Found: C, 52.20; H, 5.69; N, 6.66.

Sources & evidence

ORD record
ord-d256a1fd149a469b90c6e7ee137de717
Source dataset
uspto-grants-2005_05
Patent number
US06890942B2

Reaction notes

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