Methanesulfonamide → HCID 76169163, compound

Participants

Reaction Steps

Reaction of 4-({[2-(2,2-dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-acetyl]-methoxy-amino}-methyl)-benzoic acid tert-butyl ester (0.060 g, 0.15 mmol) with methanesulfonamide (0.014 g, 0.15 mmol) as described in the prepartion of compound 22 gave 0.043 g (67% yield) of the title amide as a white solid. 1H NMR (400 MHz, CDCl3) δ: mixture of rotamers: 1.58 (9H, s t-Bu), 3.31, 3.33 and 3.36 (3H, 3 S, SO2CH3), 3.61, 3.66 and 3.70 (3H, 3 s, OCH3), 4.8 and 4.88 (2H, 2 s, NCH2), 6.6 (1H, s, CH), 7.28 (2H, m, aromatics), 7.98 (2H, m, aromatics), 8.98 (1H, broad s, NH). HRMS (ESI/neg) calculated for C18H23N2O8S: [M−H]−: 427.117513; found: 427.117342.

Provenance & Evidence