Methanesulfonamide → HCID 72613065, compound

Participants

Reaction Steps

Reaction of 2-(2,2-dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(3-fluoro-4-methyl-benzyl)-N-methoxy-acetamide (0.135 g, 0.418 mmol) with methanesulfonamide (0.042 g, 0.44 mmol) as described in the preparation of compound 22 gave 0.102 g (68% yield) of the title amide as a white solid. 1H NMR (400 MHz, DMSO) δ: mixture of rotamers: 2.2 (3H, s, CH3), 2.87 and 2.88 (3H, 2 S, SO2CH3), 3.63 and 3.67 (3H, 2 s, OCH3), 4.73 and 4.78 (2H, 2 s, NCH2), 6.14 and 6.16 (1H, 2 s, CH), 7.04-7.27 (3H, m, aromatics). HRMS (ESI/neg) calculated for C14H16FN2O6S: [M−H]−: 359.071312; found: 359.071347.

Provenance & Evidence