Sodium cyanoborohydride → HCID 22485636, compound

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Reaction Steps

Reduction of 4,4′-difluorobenzophenone O-methyloxime with sodium cyanoborohydride as described in the preparation of 1-B gave the title hydroxylamine as a clear oil after chromatography on silica gel (elution hexane-dichloromethane 1:1) (41% yield). 1HNMR 400 MHz (CDCl3) δ (ppm): 3.49 (3H, s, OCH3), 5.18 (1H, s, NCH), 5.8 (1H, broad, NH), 7.02 (4H, m, aromatics), 7.35 (4H, m, aromatics). The hydrochloride salt was obtained as a white solid: mp 162° C. (dec). Anal. calcd for C14H13F2NO—HCl: C, 58.85; H, 4.94; N, 4.90. Found: C, 59.05; H, 4.74; N, 4.77.

Provenance & Evidence