HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → N-(5-((1R,2S)-2-(3,5-Dimethoxybenzylamino)-1-hydroxypropyl)-2-hydroxyphenyl)methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | N-(5-((1R,2S)-2-(3,5-Dimethoxybenzylamino)-1-hydroxypropyl)-2-hydroxyphenyl)methanesulfonamide | HCID 58280637 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | N-(5-((1R,2S)-2-(3,5-Dimethoxybenzylamino)-1-hydroxypropyl)-2-hydroxyphenyl)methanesulfonamide | HCID 58280637 | 55% |
Reaction Steps
4N Hydrogen chloride dioxane solution (0.04 mL) was added to the dioxane solution (1 mL) of the obtained amine (4) (47 mg, 0.11 mmol), and the mixture was freeze-dried, to give hydrochloric acid salt of the amine (4) as white solid (27 mg, yield: 55%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08198330B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-74b35d516e144b2cb5352ac44c27309c |
| Source note | uspto-grants-2012_06 |