HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Z)-2-Ethoxy-3-(1H-indol-5-yl)-acrylic Acid Ethyl Ester → Rac-2-ethoxy-3-(1h-indol-5-yl)-propionic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Z)-2-Ethoxy-3-(1H-indol-5-yl)-acrylic Acid Ethyl Ester | HCID 53309301 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Rac-2-ethoxy-3-(1h-indol-5-yl)-propionic acid ethyl ester | HCID 69563293 | 89% |
Reaction Steps
A suspension of 9.7 g of (Z)-2-ethoxy-3-(1H-indol-5-yl)-acrylic acid ethyl ester in 100 ml of EtOH and 1.0 g of Pd/C (10%) was hydrogenated at 22° C. for 2 h after which time hydrogen uptake ceased. The suspension was filtered, the filtrate evaporated and the residue chromatographed on silica (n-hexane/AcOEt, 2:1) to give 8.7 g of the title compound as a white solid. MS: (M)+ 261.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06890947B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-5b008fc36b014dc5aa3d03d8d2b8482a |
| Source note | uspto-grants-2005_05 |