反应详情

In analogy to the procedures described in preparation 1a) and 1b), 2-methyl-1H-indole-5-carbaldehyde was reacted with (1,2-diethoxy-2-oxoethyl)triphenyl phosphonium chloride in dichloromethane in the presence of tetramethyl guanidine to give (Z)-2-ethoxy-3-(2-methyl-1H-indol-5-yl)-acrylic acid ethyl ester, which was subsequently hydrogenated to yield the title compound as colorless oil.