HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-1h-indole-5-carbonitrile → 4-methyl-1H-indole-5-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-1h-indole-5-carbonitrile | HCID 22485688 | — |
| Reactant | HCID 178418950 | HCID 178418950 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Pyridinium acetate | HCID 165292 | — |
| Product | 4-methyl-1H-indole-5-carbaldehyde | HCID 22485673 | — |
Reaction Steps
In analogy to the procedure described in preparation 5a), 4-methyl-1H-indole-5-carbonitrile was reacted with sodium hypophosphite monohydrate and Raney-Nickel in acetic acid/pyridine to give 4-methyl-1H-indole-5-carbaldehyde as light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06890947B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-6e47b176a5404948a4448f940052439f |
| Source note | uspto-grants-2005_05 |