HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloromethyl-2-(2-fluoro-phenyl)-5-methyl-oxazole → 2-ethoxy-3-(1-((2-(2-fluorophenyl)-5-methyloxazol-4-yl)methyl)-1H-indol-5-yl)propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloromethyl-2-(2-fluoro-phenyl)-5-methyl-oxazole | HCID 4441114 | — |
| Reactant | Rac-2-ethoxy-3-(1h-indol-5-yl)-propionic acid ethyl ester | HCID 69563293 | — |
| Product | 2-ethoxy-3-(1-((2-(2-fluorophenyl)-5-methyloxazol-4-yl)methyl)-1H-indol-5-yl)propanoic acid | HCID 10409988 | 47% |
Reaction Steps
Starting from rac-2-ethoxy-3-(1H-indol-5-yl)-propionic acid ethyl ester and 4-chloromethyl-2-(2-fluoro-phenyl)-5-methyl-oxazole, the title compound was obtained in 47% yield as a yellow solid. MS: (M+H)+ 423.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06890947B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-ed7802cfd95a4e0fb97cf7d7626af0f0 |
| Source note | uspto-grants-2005_05 |