HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)-2-(2-chlorophenyl)-5-methyloxazole → (2S)-3-(1-{[2-(2-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-1H-indol-5-yl)-2-ethoxypropanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)-2-(2-chlorophenyl)-5-methyloxazole | HCID 21974256 | — |
| Reactant | (S)-2-ethoxy-3-(1H-indol-5-yl)-propionic acid methyl ester | HCID 69563912 | — |
| Product | (2S)-3-(1-{[2-(2-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-1H-indol-5-yl)-2-ethoxypropanoic acid | HCID 9549225 | 56% |
Reaction Steps
Starting from (S)-2-ethoxy-3-(1H-indol-5-yl)-propionic acid methyl ester and 4-chloromethyl-2-(2-chloro-phenyl)-5-methyl-oxazole, the title compound was obtained in 56% yield as a pale brown amorphous solid. MS: (M−H)− 437.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06890947B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-ecb67847b00041fa8cc3cc3ef54e87f3 |
| Source note | uspto-grants-2005_05 |