4-(Chloromethyl)-2-(2-methoxyphenyl)-5-methyl-1,3-oxazole → (Z)-2-ethoxy-3-{1-[2-(2-methoxy-phenyl)-5-methyl-oxazol-4-ylmethyl]-1H-indol-5-yl}-acrylic acid ethyl ester

Participants

Reaction Steps

In analogy to the procedures described in examples 36a) and 36b), (Z)-2-ethoxy-3-(1H-indol-5-yl)-acrylic acid ethyl ester [preparation 1a)] was reacted with 4-chloromethyl-2-(2-methoxy-phenyl)-5-methyl-oxazole to give (Z)-2-ethoxy-3-{1-[2-(2-methoxy-phenyl)-5-methyl-oxazol-4-ylmethyl]-1H-indol-5-yl}-acrylic acid ethyl ester, which was subsequently saponified to yield (Z)-2-ethoxy-3-{1-[2-(2-methoxy-phenyl)-5-methyl-oxazol-4-ylmethyl]-1H-indol-5-yl}-acrylic acid as colorless solid.

Provenance & Evidence