HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)-2-(4-ethylphenyl)-5-methyl-1,3-oxazole → (S)-2-Ethoxy-3-{1-[2-(4-ethyl-phenyl)-5-methyl-oxazol-4-ylmethyl]-1H-indol-5-yl}-propionic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)-2-(4-ethylphenyl)-5-methyl-1,3-oxazole | HCID 16003033 | — |
| Reactant | (S)-2-ethoxy-3-(1H-indol-5-yl)-propionic acid methyl ester | HCID 69563912 | — |
| Product | (S)-2-Ethoxy-3-{1-[2-(4-ethyl-phenyl)-5-methyl-oxazol-4-ylmethyl]-1H-indol-5-yl}-propionic Acid | HCID 10455512 | 47% |
Reaction Steps
Starting from (S)-2-ethoxy-3-(1H-indol-5-yl)-propionic acid methyl ester and 4-chloromethyl-2-(4-ethyl-phenyl)-5-methyl-oxazole, the title compound was obtained in 47% yield as a colourless solid. MS: (M−H)− 431.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06890947B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-fb7ef0ee579648d08219b6c3bf77eac2 |
| Source note | uspto-grants-2005_05 |