HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Trifluoromethylphenyl)-4-chloromethyl-5-methyloxazole → (S)-2-Ethoxy-3-{1-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-1H-indol-5-yl}-propionic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Trifluoromethylphenyl)-4-chloromethyl-5-methyloxazole | HCID 10236333 | — |
| Reactant | (S)-2-ethoxy-3-(1H-indol-5-yl)-propionic acid methyl ester | HCID 69563912 | — |
| Product | (S)-2-Ethoxy-3-{1-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-1H-indol-5-yl}-propionic Acid | HCID 10479921 | 50% |
Reaction Steps
Starting from (S)-2-ethoxy-3-(1H-indol-5-yl)-propionic acid methyl ester and 4-chloromethyl-5-methyl-2-(4-trifluoromethyl-phenyl)-oxazole, the title compound was obtained in 50% yield as a pale yellow solid. MS: (M−H)− 471.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06890947B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-bd675a7f0b1c43f8892d0e8b168fd6cb |
| Source note | uspto-grants-2005_05 |