HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloromethyl-2-(4-fluoro-3-methyl-phenyl)-5-methyl-oxazole → (S)-2-Ethoxy-3-{1-[2-(4-fluoro-3-methyl-phenyl)-5-methyl-oxazol-4-ylmethyl]-1H-indol-5-yl}-propionic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloromethyl-2-(4-fluoro-3-methyl-phenyl)-5-methyl-oxazole | HCID 21974259 | — |
| Reactant | (S)-2-ethoxy-3-(1H-indol-5-yl)-propionic acid methyl ester | HCID 69563912 | — |
| Product | (S)-2-Ethoxy-3-{1-[2-(4-fluoro-3-methyl-phenyl)-5-methyl-oxazol-4-ylmethyl]-1H-indol-5-yl}-propionic Acid | HCID 10026030 | 58% |
Reaction Steps
Starting from (S)-2-ethoxy-3-(1H-indol-5-yl)-propionic acid methyl ester and 4-chloromethyl-2-(4-fluoro-3-methyl-phenyl)-5-methyl-oxazole, the title compound was obtained in 58% yield as a pale yellow solid. MS: (M−H)− 435.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06890947B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-b4fde64276af487486ecf09b3897ac88 |
| Source note | uspto-grants-2005_05 |