4-(Chloromethyl)-2-phenyl-1,3-thiazole → HCID 11742072, compound

HRID 2181224Notes

Reaction equation

HRID 2181224 reaction equation
C([O:3][C:4](=[O:19])[CH:5]([O:16][CH2:17][CH3:18])[CH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][CH:11]=[CH:10]2)C.Cl[CH2:21][C:22]1[N:23]=[C:24]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[S:25][CH:26]=1>>[CH2:17]([O:16][CH:5]([CH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[N:12]([CH2:21][C:22]1[N:23]=[C:24]([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[S:25][CH:26]=1)[CH:11]=[CH:10]2)[C:4]([OH:3])=[O:19])[CH3:18]

Participants

3

Reactant 2

HCID 2369694-(Chloromethyl)-2-phenyl-1,3-thiazoleHCID 69563293Rac-2-ethoxy-3-(1h-indol-5-yl)-propionic acid ethyl ester

Product 1

HCID 11742072HCID 11742072, compoundYield 64%

Procedure

Starting from rac-2-ethoxy-3-(1H-indol-5-yl)-propionic acid ethyl ester and 4-chloromethyl-2-phenyl-thiazole, the title compound was obtained in 64% yield as a brown oil. MS: (M+H)+ 407.3.

Sources & evidence

ORD record
ord-d51d6beec57a4c6f9780b6856ed246cd
Source dataset
uspto-grants-2005_05
Patent number
US06890947B2

Reaction notes

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