HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)-5-methyl-2-phenyl-1,3-oxazole → (Z)-2-Methoxy-3-[1-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-1H-indol-5-yl]-acrylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)-5-methyl-2-phenyl-1,3-oxazole | HCID 9794289 | — |
| Reactant | (Z)-3-(1H-indol-5-yl)-2-methoxy-acrylic Acid Benzyl Ester | HCID 69563356 | — |
| Product | (Z)-2-Methoxy-3-[1-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-1H-indol-5-yl]-acrylic Acid | HCID 11740979 | 75% |
Reaction Steps
Starting from (Z)-3-(1H-indol-5-yl)-2-methoxy-acrylic acid benzyl ester and 4-chloromethyl-2-phenyl-5-methyl-oxazole, the title compound was obtained in 75% yield as an off-white solid. MS: (M+H)+ 389.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06890947B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-3e7916831cf84aa1a7bb621e77c6777a |
| Source note | uspto-grants-2005_05 |