4-(Chloromethyl)-5-methyl-2-(2-methylphenyl)-1,3-oxazole → HCID 10410562, compound

HRID 2181238Notes

Reaction equation

HRID 2181238 reaction equation
C[O:2][C:3](=[O:19])[CH:4]([O:15][CH2:16][CH2:17][CH3:18])[CH2:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][CH:10]=[CH:9]2.Cl[CH2:21][C:22]1[N:23]=[C:24]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[CH3:34])[O:25][C:26]=1[CH3:27]>>[CH3:27][C:26]1[O:25][C:24]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[CH3:34])=[N:23][C:22]=1[CH2:21][N:11]1[C:12]2[C:8](=[CH:7][C:6]([CH2:5][CH:4]([O:15][CH2:16][CH2:17][CH3:18])[C:3]([OH:2])=[O:19])=[CH:14][CH:13]=2)[CH:9]=[CH:10]1

Participants

3

Reactant 2

HCID 219742584-(Chloromethyl)-5-methyl-2-(2-methylphenyl)-1,3-oxazoleHCID 69562937Methyl α-propoxy-1H-indole-5-propanoate

Product 1

HCID 10410562HCID 10410562, compound

Procedure

In analogy to the procedure described in example 44, rac-3-(1H-indol-5-yl)-2-propoxy-propionic acid methyl ester (preparation 6) was reacted with 4-chloromethyl-5-methyl-2-o-tolyl-oxazole to give rac-3-[1-(5-methyl-2-o-tolyl-oxazol-4-ylmethyl)-1H-indol-5-yl]-2-propoxy-propionic acid as light brown oil.

Sources & evidence

ORD record
ord-f45aa024856440e4a654907e1a068b1a
Source dataset
uspto-grants-2005_05
Patent number
US06890947B2

Reaction notes

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