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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2181247Generated: November 1, 2026

4-(Chloromethyl)-5-methyl-2-(2-methylphenyl)-1,3-oxazole → rac-2-but-3-enyloxy-3-[1-(5-methyl-2-o-tolyl-oxazol-4-ylmethyl)-1H-indol-5-yl]-propionic acid

https://huagongshe.com/reaction/2181247

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Chloromethyl)-5-methyl-2-(2-methylphenyl)-1,3-oxazoleHCID 21974258—
ReactantHCID 69563491HCID 69563491—
Productrac-2-but-3-enyloxy-3-[1-(5-methyl-2-o-tolyl-oxazol-4-ylmethyl)-1H-indol-5-yl]-propionic acidHCID 10478629—

Reaction Steps

In analogy to the procedure described in example 44, rac-2-but-3-enyloxy-3-(1H-indol-5-yl)-propionic acid methyl ester (preparation 9) was reacted with 4-chloromethyl-5-methyl-2-o-tolyl-oxazole to give rac-2-but-3-enyloxy-3-[1-(5-methyl-2-o-tolyl-oxazol-4-ylmethyl)-1H-indol-5-yl]-propionic acid as light brown solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06890947B2
Source datasetuspto-grants-2005_05
ORD IDord-16d1df927d8c44af830702ea88d9c773
Source noteuspto-grants-2005_05