反应详情

In analogy to the procedures described in examples 36a) and 36b), (Z)-2-ethoxy-3-(1H-indol-5-yl)-acrylic acid ethyl ester [preparation 1a)] was reacted with 4-chloromethyl-2-(2-chloro-phenyl)-5-methyl-oxazole to give (Z)-3-{1-[2-(2-chloro-phenyl)-5-methyl-oxazol-4-ylmethyl]-1H-indol-5-yl}-2-ethoxy-acrylic acid ethyl ester, which was subsequently saponified to yield the title compound as colorless solid.