HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)-2-(4-isopropylphenyl)-5-methyloxazole → Rac-2-ethoxy-3-{1-[2-(4-isopropyl-phenyl)-5-methyl-oxazol-4-ylmethyl]-1h-indol-6-yl}-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)-2-(4-isopropylphenyl)-5-methyloxazole | HCID 21974255 | — |
| Reactant | Rac-2-ethoxy-3-(1h-indol-6-yl)-propionic acid ethyl ester | HCID 69563615 | — |
| Product | Rac-2-ethoxy-3-{1-[2-(4-isopropyl-phenyl)-5-methyl-oxazol-4-ylmethyl]-1h-indol-6-yl}-propionic acid | HCID 10478746 | — |
Reaction Steps
In analogy to the procedure described in example 44, rac-2-ethoxy-3-(1H-indol-6-yl)-propionic acid ethyl ester (preparation 11) was reacted with 4-chloromethyl-2-(4-isopropyl-phenyl)-5-methyl-oxazole to give rac-2-ethoxy-3-{1-[2-(4-isopropyl-phenyl)-5-methyl-oxazol-4-ylmethyl]-1H-indol-6-yl}-propionic acid as light yellow viscous oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06890947B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-094e048525d94d6dae79768f179fa053 |
| Source note | uspto-grants-2005_05 |