Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | HCID 20781270 | HCID 20781270 | — |
| Reactant | HCID 178418260 | HCID 178418260 | — |
| Catalyst | Pyridine | HCID 1049 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 20781271 | HCID 20781271 | 66% |
Reaction Steps
A solution of the compound prepared in Example 75 (45 mg) was treated with copper cyanide (4 equivalents), pyridine (1 drop) and dimethylformamide (3 ml) and heated at 180° C. overnight. The reaction was diluted with ethyl acetate and water and filtered. The organic layer of the filtrate was washed with water and brine and dried, filtered and evaporated in vacuo. Purification by column chromatography gave the nitrile (27 mg, 66%). M/Z=559 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06890956B2 |
|---|
| Source dataset | uspto-grants-2005_05 |
|---|
| ORD ID | ord-b88039147a8145c788a8970de6ba400d |
|---|
| Source note | uspto-grants-2005_05 |
|---|
