Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetramethyltin | HCID 11661 | — |
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| Reactant | HCID 20781270 | HCID 20781270 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 20781242 | HCID 20781242 | — |
Reaction Steps
The compound prepared in Example 75 (50 mg) in dioxane was treated with cesium fluoride (2.2 equivalents), tri-tert-butylphosphine (12 mol %), tetramethyltin (2 equivalents), and Pd2(dba)3 (3 mol %) and heated at 100° C. for 3 h. The reaction mixture was cooled, diluted with ether, filtered and the filtrate evaporated in vacuo. Purification by column chromatography gave the toluene derivative (13 mg, 29%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06890956B2 |
|---|
| Source dataset | uspto-grants-2005_05 |
|---|
| ORD ID | ord-e5808a180fac4f5085308848a2a79509 |
|---|
| Source note | uspto-grants-2005_05 |
|---|
