MRK 560 → HCID 20781272, compound

Participants

Reaction Steps

A solution of the product from Example 47 (0.28 g, 0.6 mmol) was flushed with nitrogen, 10% palladium on carbon (0.03 g, 10% w/w) was added, and the mixture was hydrogenated at 40 psi for 16 hours. Filtration and evaporation in vacuo gave the product (0.28 g, 99%). 1H NMR (CDCl3, 400 MHz): 1.61-1.68 (2H, m), 2.03-2.07 (2H, m), 2.44 (2H, bt, J=13.2), 2.63 (2H, bd, J=13.5), 3.78-3.82 (1H, m), 5.64 (1H, d, J=8.4), 6.78-6.85 (1H, m), 6.99-7.08 (2H, m), 7.38-7.43 (4H, m), 7.60-7.65 (1H, m).

Provenance & Evidence