HCID 22485624, compound → HCID 22485474, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-nitro-2-(3,4,5-trimethoxyphenyl)-pyridine (1.50 g, 5.17 mmol) in methanol-ethyl acetate (1:4, 50 mL) was added 10% palladium on charcoal (158.6 mg), and the resulting mixture was stirred at 45° C. for 2 hours and 30 minutes under hydrogen. Insoluble materials were removed by filtration through Celite, and the filtrate was concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-hexane to yield the title compound as colorless needles (melting point: 153.5-155.5° C. )(1.25 g, yield: 93%).

Provenance & Evidence