Hydrochloric Acid → HCID 22485589, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N,N′-dibenzyl-N,N′-dimethyl-3-(1-pyrrolidinyl)-1,5-pentanediamine (249.1 mg, 0.657 mmol) in methanol (3.0 mL) were added concentrated hydrochloric acid (0.33 mL, 4.0 mmol) and 10% palladium on charcoal (50.0 mg), and the mixture was stirred at 50° C. for 14 hours under hydrogen. Insoluble materials were removed by filtration through a membrane filter, and the filtrate was concentrated under reduced pressure. The residue was adsorbed on an alumina column, and eluted with methanol-chloroform (1:4). The eluate was concentrated under reduced pressure to afford the title compound as a colorless oil (101.9 mg, yield: 78%).

Provenance & Evidence