Methanesulfonic Acid → HCID 22485601, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N,N′-bis[2-(4-cyano-3,5-dimethoxy-phenyl)-5-pyridyl]-N,N′-dimethylethylenediamine (125.0 mg, 0.220 mmol) in methanol (2.0 mL) was added a 1.0 M aqueous methanesulfonic acid solution (0.44 mL, 0.44 mmol), and the reaction mixture was concentrated under reduced pressure. Ethanol (5.0 mL) was added to the residue, and the mixture was concentrated under reduced pressure. Methanol (2.5 mL) was added to the residue, and the resulting suspension was stirred in a bath maintained at 70° C. After cooling, the resulting precipitate was collected by filtration to afford the title compound as a yellow crystalline powder (melting point:≧300.0° C.)(72.0 mg, yield: 43%).

Provenance & Evidence