Methanesulfonic Acid → HCID 22485460, compound

Participants

Reaction Steps

To a solution of 1,4-bis[2-(3,4,5-trimethoxyphenyl)-5-pyridyl]hexahydro-1,4-diazepine (88.0 mg, 0.150 mmol) in methanol-methylene chloride (1:1, 4.0 mL) was added a 1.0 M aqueous methanesulfonic acid solution (0.30 mL, 0.30 mmol), and the reaction mixture was concentrated under reduced pressure. Ethanol (5.0 mL) was added to the residue, and the mixture was concentrated under reduced pressure. The residue was recrystallized from methanol-methylene chloride-diethyl ether to yield the title compound as yellow prisms (melting point: 246.0-248.0° C.)(93.0 mg, yield: 79%).

Provenance & Evidence