Methanesulfonic Acid → HCID 22485585, compound

Participants

Reaction Steps

To a solution of the crude N,N′-bis[2-(3,4,5-trimethoxyphenyl)-5-pyridyl]-N,N′-diethyl-1,3-propanediamine (160.0 mg, approx. 0.26 mmol) in methanol-chloroform (1:1, 6.0 mL) was added a 1.0 M aqueous methanesulfonic acid solution (0.51 mL, 0.51 mmol), and the reaction mixture was concentrated under reduced pressure. Ethanol (5.0 mL) was added to the residue, and the mixture was concentrated under reduced pressure. The residue was recrystallized from methanol-methylene chloride-diethyl ether to yield the title compound as a yellow crystalline powder (melting point: 239.0-242.0° C.)(92.0 mg, yield: 45% based on N,N′-diethyl-1,3-propanediamine).

Provenance & Evidence