Methanesulfonic Acid → HCID 22485533, compound

Participants

Reaction Steps

To a solution of N,N′-bis[2-(3,4,5-trimethoxyphenyl)-5-pyridyl]-4,4′-bipiperidine (228.0 mg, 0.340 mmol) in methanol-chloroform(1:1, 6.0 mL) was added a 1.0 M aqueous methanesulfonic acid (0.70 mL, 0.70 mmol), and the reaction mixture was concentrated under reduced pressure. Ethanol (5.0 mL) was added to the residue, and the mixture was concentrated under reduced pressure. The residue was recrystallized from methanol-methylene chloride-diethyl ether to yield the title compound as yellow needles (melting point: 226.0-228.0° C.)(170.0 mg, yield: 59%).

Provenance & Evidence