HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Methylamino)ethanol → HCID 10164546, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Methylamino)ethanol | HCID 8016 | — |
| Reactant | HCID 22484120 | HCID 22484120 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Solvent | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Solvent | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Product | HCID 10164546 | HCID 10164546 | — |
Reaction Steps
The product of step b) (98 mg) was dissolved in 1-methyl-2-pyrrolidinone (NMP) (1 ml) to which EDCl (1 ml), HOBT (1 ml) and N-methyl ethanolamine (1 ml) was added. The reaction was stirred for 18 hrs before being concentrated in vacuo. The residue was partitioned between dichloromethane and water. The organic phase was adsorbed onto silica and purified by chromatography eluting with 0-10% methanol in dichloromethane to yield the title compound (62 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06890923B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-b592662b765f44bab9fecfa4c32cb5a3 |
| Source note | uspto-grants-2005_05 |