HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,3,3-Trifluoropropionic acid → 3,3,3-trifluoro-N-((2-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-phenylcyclopropyl)methyl) propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,3,3-Trifluoropropionic acid | HCID 2777972 | — |
| Reactant | (2-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-phenylcyclopropyl)methanamine | HCID 68707146 | — |
| Product | 3,3,3-trifluoro-N-((2-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-phenylcyclopropyl)methyl) propanamide | HCID 59251105 | 86% |
Reaction Steps
(2-(1-(4-Fluorophenyl)-1H-indazol-5-yl)-2-phenylcyclopropyl)methanamine (71 mg, 0.15 mmol) was coupled with 3,3,3-trifluoropropanoic acid (38 mg, 0.2 mmol) using General Coupling Method A to give 60 mg (86% yield) of 3,3,3-trifluoro-N-((2-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-phenylcyclopropyl)methyl) propanamide. MS found: (M+H)+=468.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08198311B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-ad52d61aa2db4273ad52af6fc76d3db4 |
| Source note | uspto-grants-2012_06 |