HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-Trifluoroethanesulfonyl chloride → 2,2,2-trifluoro-N-((2-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-phenylcyclopropyl)methyl)ethanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-Trifluoroethanesulfonyl chloride | HCID 74242 | — |
| Reactant | (2-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-phenylcyclopropyl)methanamine | HCID 68707146 | — |
| Product | 2,2,2-trifluoro-N-((2-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-phenylcyclopropyl)methyl)ethanesulfonamide | HCID 59251061 | 86% |
Reaction Steps
(2-(1-(4-Fluorophenyl)-1H-indazol-5-yl)-2-phenylcyclopropyl)methanamine (71 mg, 0.15 mmol) was coupled with 2,2,2-trifluoroethanesulfonyl chloride (50 mg, 0.5 mmol) using General Coupling Method B to give 60 mg (86% yield) of 2,2,2-trifluoro-N-((2-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2-phenylcyclopropyl)methyl)ethanesulfonamide. MS found: (M+H)+=504.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08198311B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-56148a97f10e49ce8720e759de4a52e9 |
| Source note | uspto-grants-2012_06 |