反应详情

A solution of 1-nitroso-2-naphthol (0.50 g, 2.89 mmol) and 1,3-dimethyl-3-carboethoxy-2-methylene-indoline (0.87 g, 2.77 mmol) in ethanol (70 ml) was heated under nitrogen and refluxed for 2 hrs. The solvent was then evaporated and the residue was chromatographed over silica (ethyl acetate/petroleum ether 1:10). After crystallization in ethanol, the yield of the pure product (colorless crystals) was 0.21 g (16%).

1. temperaturerefluxed for 2 hrs
2. customThe solvent was then evaporated
3. customthe residue was chromatographed over silica (ethyl acetate/petroleum ether 1:10)
4. customAfter crystallization in ethanol