Cyclopentylamine → 5Chloro-2-(4fluorophenyl)imidazo[4,5-b]pyridine

Participants

Role	Name	HCID	Charge
Reactant	Cyclopentylamine	HCID 2906	—
Reactant	5-Chloro-2-(4-fluorophenyl)-1-(2-methylsulfinyl-4-pyrimidinyl)imdazo[4,5-b]pyridine	HCID 22486127	—
Product	5Chloro-2-(4fluorophenyl)imidazo[4,5-b]pyridine	HCID 22486125	38.8%

Reaction Steps

5-Chloro-2-(4-fluorophenyl)-1-(2-methylsulfinyl-4-pyrimidinyl)imidazo[4,5-b]pyridine (200 mg 0.52 mmol) and cyclopentylamine (1 ml) are heated to 80° C. for 1 h, evaporated and purified by SiO2 chromatography (acetone/cyclohexane 10/90 to 20/80) to yield the title compound as white crystals (50 mg 24%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06891039B2
Source dataset	uspto-grants-2005_05
ORD ID	ord-06d34a2ac07f41e1965d22756672b1b7
Source note	uspto-grants-2005_05