HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylvinyltin → 5Chloro-2-(4fluorophenyl)imidazo[4,5-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylvinyltin | HCID 81998 | — |
| Reactant | 5-Chloro-2-(4-fluorophenyl)-1-(2-cyclopentylamino-4-pyrimidinyl)imidazo[4,5-b]pyridine | HCID 22486152 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 5Chloro-2-(4fluorophenyl)imidazo[4,5-b]pyridine | HCID 22486125 | 141.3% |
Reaction Conditions
| Temperature | 160 °C |
|---|
Reaction Steps
2-(4-Fluorophenyl)-1-(2-cyclopentylamino-4-pyrimidinyl)-5-chloroimidazo[4,5-b]pyridine (50 mg 0.12 mmol), vinyltributylstannane (4.3 ml 0.15 mmol) and PdCl2(PPh3)2 (8.6 mg 0.01 mmol) are dissolved in xylene (1 ml) and heated to 160° C. for 1 h under argon. The reaction mixture is purified over SiO2 (acetone/hexanes 15/85) to yield the title compound as colorless crystals (42 mg 86%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06891039B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-b18448ed9fd14013ad73d5b6df265a01 |
| Source note | uspto-grants-2005_05 |