Ammonium Chloride → HCID 24936969, compound

Participants

Reaction Steps

To a solution of 1-tert-butyl-3-(3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethylhex-5-enyl)urea (20 mg, 0.046 mmol) in anhydrous DCE (2 mL) at −10 C was added diethylzinc solution (0.46 mL, 0.46 mmol) and methyldiiodide (245 mg, 0.92 mmol) under nitrogen. Allowed reaction mixture to warm to RT and stirred overnight. The mixture was poured into sat NH4Cl, extracted with DCM (2×10 mL), dried (Na2SO4) and purified by HPLC to give 11 mg (50% yield) of 1-tert-butyl-3-(4-cyclopropyl-3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethylbutyl)urea. MS found: (M+H)+=451.

Provenance & Evidence