3,3,3-Trifluoropropionic acid → HCID 59251136, compound

HRID 218160Notes

Reaction equation

HRID 218160 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([CH:17]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[CH2:18][CH2:19][NH2:20])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[F:27][C:28]([F:34])([F:33])[CH2:29][C:30](O)=[O:31]>>[F:27][C:28]([F:34])([F:33])[CH2:29][C:30]([NH:20][CH2:19][CH2:18][CH:17]([C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[N:8]([C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1)[N:9]=[CH:10]2)[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:31]

Participants

3

Reactant 2

HCID 27779723,3,3-Trifluoropropionic acidHCID 68706330HCID 68706330, compound

Product 1

HCID 59251136HCID 59251136, compoundYield 97%

Procedure

Prepared from 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-3-phenylpropan-1-amine (25 mg, 0.05 mmol) and 3,3,3-trifluoropropionic acid using General Coupling Method A to give 24 mg (97%) of 3,3,3-trifluoro-N-(3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-3-phenylpropyl)propanamide. MS found: (M+H)+=456.

Sources & evidence

ORD record
ord-4f1ae627dc8c4f1c9c43663e52f606d0
Source dataset
uspto-grants-2012_06
Patent number
US08198311B2

Reaction notes

Loading…